In this episode 14 protocols
▶ 3:17 MDMA-Assisted Therapy Behaviors “And when I say appropriate, that means in conjunction with nine therapy sessions. So this is an area that really deserves some time for us to discuss, because again, there is a distinct difference between the recreational and the therapeutic use of MDMA.” ▷ 34:59 fMRI Machine Tools “So for instance, you could take a person who's never ingested MDMA and put them into an fMRI machine... Then of course, you could give somebody MDMA while they are in the fMRI machine and see how the activation of different brain networks changes.” ▷ 43:15 MDMA Supplements “The typical dosages of MDMA used in these neuroimaging studies and in the clinical studies of PTSD... range anywhere from 0.75 milligrams per kilogram of body weight to 1.5 milligrams per kilogram of body weight. ... And then a so-called booster of half that amount, about 90 minutes to two and a half hours into the session.” ▷ 1:17:19 Avoid Gray-Market MDMA Behaviors “I also want to highlight the fact that nowadays all recreational drugs, but certainly MDMA included are often, in fact, very often contaminated with fentanyl. ... And there have been a lot of fentanyl related deaths, both in kids and adults.” ▷ 1:19:32 Avoid Caffeine With MDMA Behaviors “If you've heard that taking caffeine within the hours or same day as MDMA can increase the toxicity of MDMA, that does appear to be true based on animal studies.” ▷ 1:26:07 Avoid Combining MDMA With Other Stimulants Behaviors “Certainly we can expect that because of the huge known variation in dopamine receptors, in serotonin receptors, and of course, because of the known interactions between MDMA and other compounds, in particular caffeine, but also drugs such as cocaine or other stimulants, that some people might experience more toxicity to a given dose of MDMA compared to somebody else.” ▷ 1:33:39 Drink Fluids and Electrolytes During MDMA Use Diet “And if that's done in an environment in which there's very little temperature regulation. So people aren't, for instance, drinking enough fluids and electrolytes, it's very hot in the room. You can get neurotoxicity based on temperature effects.” ▷ 1:35:24 Control Environmental Temperature During MDMA Use Behaviors “Is it MDMA while moving around a lot or being outdoors or being in a environment, perhaps a rave or dance type environment where temperature is going up? Well, in that case, it could be very neurotoxic.” ▷ 1:39:07 Avoid 5-HTP, L-Tryptophan, L-Tyrosine, and Magnesium After MDMA Supplements “That said, you will see protocols that people have put out on the internet, such as, oh, you know, after taking MDMA, you should take a bunch of, you know, 5-HTP or other precursors to serotonin or dopamine... There's really no evidence that any of those things can be beneficial. And there is actually some reason to believe that it might be detrimental.” ▷ 1:40:54 Cabergoline Supplements “This is why drugs like cabergoline, for instance, that increase dopamine are used as ways to suppress prolactin. ... To my knowledge, there are no human data yet exploring the use of P5P or other vitamin B6 derivatives or cabergoline or things of that sort to reduce prolactin.” ▷ 1:41:26 P5P Supplements “And for that reason, some people have started to explore the use of things like P5P, which is essentially a metabolite of vitamin B6, which is known to suppress prolactin as a way to try and buffer some of that crash. ... this P5P suppression of prolactin is perhaps the one that's most intriguing and that really has any kind of mechanistic basis.” ▷ 1:45:06 Quality Talk Therapy Behaviors “Now, the treatment of trauma has been met with some degree of success through quality talk therapy. Let's define quality talk therapy in the way that Dr. Paul Conti did on this episode. That's talk therapy for which the patient... and the therapist... has good rapport.” ▷ 1:59:18 Eye Mask Tools “They are either spending time with their eyes closed lying down, sometimes in an eye mask and thinking about the trauma, thinking about their current state and experience.” ▷ 2:04:23 EMDR Behaviors “by talk therapy combined with ssris or talk therapy combined with any drug treatment or behavioral treatment like emdr eye movement desensitization reprogramming or other forms of treatments that are designed to rewire neural circuitry almost always involve the patient”