Behaviors4 mentions

Caffeine Abstinence for a Stronger Challenge-Day Boost

For an important mental or physical challenge, avoid caffeine for about 2 days beforehand, then take it roughly 30 minutes before performance. The short abstinence can restore caffeine sensitivity, making the same dose feel stronger and more ergogenic on the day that matters.

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“Now, for people that want to get more of a true cognitive enhancing and performance enhancing effect from caffeine, I would recommend a little bit of caffeine. Again, you're going to have to abstain from caffeine for about four days.”

huberman · AMA #8: Balancing Caffeine, Decision Fatigue & Social Isolation · Jun 23, 2023 · 10:46 · open ↗

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