A choline donor used mainly as a pre-workout or cognitive supplement, commonly taken in single doses around 300–600 mg for performance and sometimes split into multiple doses totaling up to about 1,200 mg/day in study settings. It’s used to support acetylcholine production, which may help power output, focus, and other aspects of mental and physical performance.
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“I'll take alpha-GPC before a workout sometimes... if I really have to push, push, push... I'll take some Alpha GPC... I take 600 milligrams. You can take up to 900, but I do just fine on 600.”
huberman · The Best Vitality & Health Protocols | Dr. Rhonda Patrick · Mar 23, 2026 · 3:08:34 · open ↗