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Supplements14 mentions

A potent glucose-lowering supplement used with doses explored around 0.5–1.5 g per day. It’s often discussed as having effects comparable to medications like metformin or glibenclamide, so it should be treated seriously and used with medical guidance. The main appeal is its ability to improve blood sugar control through a strong metabolic effect.

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Berberine actually slightly decreases the conversion to TMAO as well, probably through alteration of the gut microbiome.

Andrew Huberman · Essentials: Tools for Hormone Optimization in Males | Dr. Kyle Gillett · Jul 2, 2026 · 16:13 · YouTube ↗
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