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Supplements16 mentions

Ashwagandha

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A commonly used adaptogenic supplement taken to help lower cortisol and blunt stress reactivity. The dominant guidance is to use it in short bursts rather than continuously, with one recommendation warning against chronic use beyond about two weeks of regular dosing. Its appeal is that it may act as a fairly potent cortisol reducer, though the evidence base is still limited.

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So the limit seems to be about 2 weeks of of regular use before you'd want to take a break of about 2 weeks. So ashwagandha again a very potent inhibitor of cortisol but with some other effects as well.

Andrew Huberman · Understanding & Controlling Aggression | Huberman Lab Essentials · May 14, 2026 · 27:17 · YouTube ↗
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