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A vitamin B6 metabolite used as a recovery aid after MDMA, typically taken with the goal of blunting the comedown. The rationale is that P5P may suppress prolactin, which could help with mood and recovery after the drug wears off, though the evidence cited is mechanistic rather than based on human clinical trials.
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“And for that reason, some people have started to explore the use of things like P5P, which is essentially a metabolite of vitamin B6, which is known to suppress prolactin as a way to try and buffer some of that crash. ... this P5P suppression of prolactin is perhaps the one that's most intriguing and that really has any kind of mechanistic basis.”
huberman · The Science of MDMA & Its Therapeutic Uses: Benefits & Risks | Huberman Lab Podcast · Jun 12, 2023 · 1:41:26 · open ↗
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