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Supplements3 mentions

Take about 1 to 3 g per day of betaine as a steady daily supplement. It’s especially useful for people with persistently elevated homocysteine, since betaine helps support methylation and homocysteine recycling. Some also use it when they seem to be a creatine non-responder, and there’s no need to cycle it.

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Another one we can loop in with creatine is beta-ene some people are non-responders to creatine so you can increase that to 10 grams or you can use its cousin beta-ene to help with amino acid synthesis and shunting of energy.

Andrew Huberman · Essentials: Tools for Hormone Optimization in Males | Dr. Kyle Gillett · Jul 2, 2026 · 13:19 · YouTube ↗
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