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Supplements3 mentions

Low-Dose Naltrexone

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A low-dose naltrexone protocol used at roughly one-tenth the usual naltrexone dose, most often discussed for certain forms of fibromyalgia. The idea is that this very small dose may reduce glial activation via Toll-like receptor 4 blockade, which can help with pain and symptom burden.

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But it turns out that a very low dose...... has been shown to have some success in dealing with and treating certain forms of fibromyalgia. And it has that success because of its ability to bind, to unblock these toll4 receptors on glia.

Andrew Huberman · How to Control Your Sense of Pain & Pleasure | Huberman Lab Essentials · Jun 19, 2025 · 18:09 · YouTube ↗
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