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Supplements4 mentions

Huperzine A

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An over-the-counter acetylcholine-boosting compound used to create a short-lived window of enhanced plasticity, often paired with exercise. It works by increasing cholinergic signaling, which can also support downstream dopamine activity in brain regions tied to learning and focus.

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Supplements that I have used and do use for increasing acetylcholine are things like alpha-GPC or huperzine. Alpha-GPC is in the choline pathway such that more acetylcholine is synthesized after you ingest it.

Andrew Huberman · Control Your Brain Chemistry for Focus, Motivation & Well-Being | Huberman Lab Essentials · Aug 6, 2026 · 24:41 · YouTube ↗
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