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Supplements4 mentions

A boron supplement protocol used to help regulate sex hormone-binding globulin, with the effect described as mostly acute. A common approach is 3 to 6 mg once or twice daily, and some suggest cycling it rather than taking it continuously. The appeal is its potential to shift SHBG and thereby influence free hormone availability.

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Let's also mention boron. So if you have a very high SHBG, boron can acutely help lower it, usually in a dose of 5 to 12 milligrams per day.

Andrew Huberman · Essentials: Tools for Hormone Optimization in Males | Dr. Kyle Gillett · Jul 2, 2026 · 18:19 · YouTube ↗
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