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Skip Psilocybin Microdosing
This recommendation is to avoid taking tiny, repeated doses of psilocybin as a wellness or productivity strategy. The rationale is that the evidence for microdosing benefits is essentially absent, especially compared with the stronger evidence base for a single, full psychedelic session. In other words, the proposed upside is unproven while the practice still carries drug-related risks and uncertainty.
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“My read of the literature, and this might have been updated since, is that there is zero evidence that microdosing psilocybin has any benefit.”
huberman · How to Overcome Addiction to Substances or Behaviors | Dr. Keith Humphreys · Jan 12, 2026 · 1:12:42 · open ↗
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