Avoid Psychedelics With Psychosis or Bipolar Risk

Avoid psilocybin and related psychedelics if you have a personal history of psychosis, bipolar disorder, or prior manic/psychotic episodes, and be cautious if a first-degree relative has schizophrenia, bipolar disorder, schizotypal disorder, or similar conditions. The rationale is that these substances can precipitate or worsen mania and psychosis in vulnerable people, and most clinical studies exclude such participants for safety.