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Supplements2 mentions

A powerful plant-medicine psychedelic used in a controlled, curated, physician-assisted setting. In the cited protocol it was paired with ibogaine two days apart as an intensive “nuclear option” approach. The appeal is its potential for a profound, high-impact reset, but it is explicitly not appropriate for everyone.

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The next day you do 5-MeO DMT, and that's the ego death.

huberman · How to Make Yourself Unbreakable | DJ Shipley · Oct 6, 2025 · 2:30:14 · open ↗
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