Supplements1 mentions

SAMe

SAMe has shown benefit for various types of pain and, in some studies, worked at least as well as naproxen at certain dosages. Pain-relieving effects may take up to about a month to appear.

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“SAMe in particular has been interesting because it's been shown head-to-head with drugs like naproxen and other drugs of that sort... to work at least as well as some of those compounds at certain dosages. But it's also been shown that SAMe and some of those things take more time in order to have those effects.”

huberman · How to Control Your Sense of Pain & Pleasure · Aug 9, 2021 · 1:13:05 · open ↗

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