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Avoid topical spironolactone unless prescribed
Topical spironolactone was said to be systemically absorbed; males were specifically warned not to use it unless prescribed by a doctor.
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“Of note, spironolactone can be prescribed topically, but it is absorbed systemically because of the size of the molecule. So unless your doctor specifically prescribes that for you, especially as a male, do not use topical spironolactone.”
Andrew Huberman · Essentials: Tools for Hormone Optimization in Males | Dr. Kyle Gillett · Jul 2, 2026 · 35:13 · YouTube ↗
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