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Topical Dutasteride
Shop on AmazonDiscussed as likely only minimally systemically absorbed and not affecting systemic DHT, making it a potentially preferable topical antiandrogen for hair loss.
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“Topical dutasteride is likely a tiny bit systemically absorbed, but it's unique because its half-life is much faster at a lower dose. So topical dutasteride will not affect your systemic DHT at all.”
Andrew Huberman · Essentials: Tools for Hormone Optimization in Males | Dr. Kyle Gillett · Jul 2, 2026 · 35:45 · YouTube ↗
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