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Behaviors1 mentions

Take ADHD Medication Early in the Day and Protect Sleep

Because late-day stimulant effects can impair sleep and elevate cortisol late in the day, timing should generally favor earlier dosing when possible and as worked out with a psychiatrist; choose drug type and timing with sleep preservation in mind, and for some people short-acting options may be preferable.

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In fact, late day elevations in cortisol are a strong correlate of depressive symptoms.

huberman · Adderall, Stimulants & Modafinil for ADHD: Short- & Long-Term Effects · May 29, 2023 · 1:23:24 · open ↗
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