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Behaviors1 mentions

Avoid Caffeine With MDMA

Avoid caffeine on the day of MDMA use, and ideally the day before and day after as well, because caffeine may increase MDMA neurotoxicity.

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If you've heard that taking caffeine within the hours or same day as MDMA can increase the toxicity of MDMA, that does appear to be true based on animal studies.

Andrew Huberman · The Science of MDMA & Its Therapeutic Uses: Benefits & Risks | Huberman Lab Podcast · Jun 12, 2023 · 1:19:32 · open ↗
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