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Avoid 5-HTP, L-Tryptophan, L-Tyrosine, and Magnesium After MDMA

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Common post-MDMA crash supplement protocols using serotonin or dopamine precursors and magnesium are not evidence-based. 5-HTP, L-tryptophan, L-tyrosine, and magnesium may not aid recovery and could be detrimental.

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That said, you will see protocols that people have put out on the internet, such as, oh, you know, after taking MDMA, you should take a bunch of, you know, 5-HTP or other precursors to serotonin or dopamine... There's really no evidence that any of those things can be beneficial. And there is actually some reason to believe that it might be detrimental.

huberman · The Science of MDMA & Its Therapeutic Uses: Benefits & Risks | Huberman Lab Podcast · Jun 12, 2023 · 1:39:07 · open ↗
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