All protocols

Start very low and go slowly with semaglutide or tirzepatide rather than using conventional doses; intended to reduce excessive weight loss, muscle loss, and nausea.

During GLP-1 use, aim for losing less than or equal to 2 pounds per week to reduce muscle loss.

Physician-prescribable anabolic steroid that can be combined with testosterone; described as helping joints and bone-related issues in some contexts.

Repeatedly emphasized as foundational before considering more aggressive interventions like testosterone; includes eating mostly non-processed foods.

Mentioned as one option to help rebuild fertility and sperm production after testosterone suppression.

Compounded combination intended to address muscle loss associated with tirzepatide by stimulating growth hormone release with sermorelin.

Suggested physician-prescribed substitute for BPC-157. Starting dose 250-500 mcg; they are using 500 mcg injected daily, Monday through Friday with weekends off.

Protocol given for pentadeca-arginate: 500 micrograms injected daily on weekdays with weekends off.

He stated he does not like testosterone pellets or pellet therapy because they expose people to hormone concentrations not seen in nature.

Timing recommendation for ipamorelin: pre-sleep/bedtime.

For bedtime use of ipamorelin and similar peptides, avoid carbohydrates in the prior 45 minutes; Huberman also mentions prior 2 hours, but guest confirms 45 minutes technically.

Recommended specifically for people trying to put on size or get stronger because it increases appetite.

Rather than using one peptide at a time, combine peptides synergistically, sometimes at lower doses, often in one compounded shot.

Example stack of BPC, ipamorelin, and tesamorelin was taken at bedtime.

Recommended schedule derived from traditional growth hormone dosing; also aligned with his general preference for taking breaks from compounds.

200 milligrams per day in the morning.

He reports bedtime use woke him from sleep with hunger and ruined sleep.

Timing recommendation for hexarelin: morning use for clean energy/endurance support.

Recommended as a methyl donor to support methylation and lower homocysteine.

Recommended as a methyl donor; described as an amino acid that can support lowering homocysteine.

Preferred timing is morning; also suggested as an option at 3 PM instead of reaching for coffee or a donut during an afternoon slump.

Recommended at bedtime to help settle the nervous system and support sleep; starting dose 3-5 grams at bedtime, and if no effect after a few nights, increase to 10 grams. Also recommended as part of liver mitigation strategies because it supports phase 2 liver detoxification. Pinealon was mentioned as something he likes combining with glycine for sleep support.

Recommended to support phase 2 liver activity via dietary polyphenols and pigments.

Recommended specifically because it has a strong inducing effect on phase 2 liver activity.

Support phase 2 liver detoxification with this practice, which is often used intravenously.

Timing recommendation for methylene blue: morning, because it is a cognitive stimulant.

His personal frequency recommendation/preference; notes some people may need it more often.

Recommended initial protocol for IV NAD.

After loading dose, average maintenance recommendation is once per month.

Alternative to IV NAD; 100 mg subcutaneously, 5 days on and 2 days off. May cause some stomach cramping.