All protocols

An intermittent rapamycin protocol used as a geroprotective intervention, commonly taken at 8 mg once per week rather than daily. One described pattern is about two months on followed by one month off to reduce aphthous ulcers/canker sores. The appeal is its reputation as a strong longevity-focused molecule, with the dosing schedule aimed at preserving the anti-aging signal while improving tolerability.

An injectable PCSK9-lowering treatment used on a regular schedule, commonly every two weeks. It is used to drive LDL and ApoB down very aggressively, making it one of the most potent options for reducing atherogenic cholesterol burden.

A cholesterol-lowering medication that reduces intestinal absorption of cholesterol, typically used to help lower LDL levels. It’s generally well tolerated, with occasional loose stools and a small risk of elevated transaminases when combined with statins.

Aim for very low apolipoprotein B as a cardiovascular risk-reduction strategy, with especially aggressive targets in higher-risk people. The practical approach is to use lifestyle changes and, when needed, lipid-lowering therapy to push ApoB down well below standard “normal” ranges, because fewer ApoB-containing particles generally means less plaque formation and lower long-term heart disease risk.

Skip smokeless tobacco products such as dipping, chewing tobacco, and snuff. These habits expose the mouth and nasal passages to carcinogens and are linked to much higher risks of cancers of the oral cavity, gums, mucosal lining, and nose, while also harming teeth and gum health.

While sitting for long periods with the knee bent about 90 degrees, repeatedly lift the heel a small amount while pressing through the toes, keeping the movement going fairly continuously. This seated soleus-focused motion is meant to mimic some of the metabolic effects of walking and can meaningfully improve blood glucose utilization during prolonged sitting.

Do one dedicated weekly resistance workout for the torso, covering chest, shoulders, and back with both pushing and pulling movements. Common exercises include overhead presses, dips, bench press, rows, pull-ups, and chin-ups, with the exact selection adjusted to your equipment and goals. Organizing the work this way can improve time efficiency while ensuring balanced upper-body development.

When a workout gets disrupted by travel, work, or family demands, move it one day earlier or later instead of skipping it. This small buffer preserves the weekly training rhythm and makes the plan more resilient, which helps you stay consistent over time rather than falling off after one missed session.

Keep the bedroom reserved for sleeping and sexual intimacy, and avoid using it for TV, eating, hanging out, or other wakeful activities. This helps train your brain to associate the room with sleep, which can make it easier to fall asleep and may reduce insomnia-like sleep problems.

Refrain from using cannabis throughout pregnancy and while breastfeeding, including THC- and CBD-containing products in smoked, vaped, edible, or dispensary forms. The rationale is that cannabinoid signaling plays an important role in fetal brain development, and exposure may interfere with normal wiring during a critical period.

If you’re so hungry that it would keep you awake, have a small snack rather than forcing yourself to stay fasted. Keep it light and avoid a large meal right before bed; the goal is to reduce gnawing hunger enough to fall asleep while still minimizing the sleep-disrupting effects of late eating.

This recommendation is to avoid taking tiny, repeated doses of psilocybin as a wellness or productivity strategy. The rationale is that the evidence for microdosing benefits is essentially absent, especially compared with the stronger evidence base for a single, full psychedelic session. In other words, the proposed upside is unproven while the practice still carries drug-related risks and uncertainty.

This recommendation is to avoid inhaling cannabis by smoking it, especially if you’re concerned about endocrine effects. The rationale given is that smoked cannabis may lower testosterone while raising prolactin and aromatase activity, which can also push estrogen higher.

For weight loss, pick the form of dietary restriction you can actually maintain long term, rather than forcing the most aggressive plan. That might mean reducing certain foods or nutrients, using time-restricted eating/intermittent fasting, or simply cutting calories in a way that feels manageable. The advantage is better adherence, which makes the diet more effective in practice than a stricter plan you cannot stick with.

Use your menstrual cycle as a cue to check in, but don’t automatically deload or change workouts just because of the phase. Keep training hard and progressively when you feel normal, and only reduce intensity or volume when cramps, fatigue, low motivation, or other symptoms are actually limiting performance. This preserves consistency while still respecting real day-to-day recovery needs.

Take 1,000 mg of lion’s mane daily as an adaptogenic supplement, then cycle off after about 30 days. It’s used to help buffer stress, with a proposed benefit of lowering cortisol and inflammatory cytokines.

When you feel a sniffle coming on or are already starting to get sick, cut the session short and make it easier: trim about 15 minutes, reduce total sets, and avoid sets to failure or hard endurance efforts. The goal is to lower overall stress on the body so you can recover instead of pushing deeper into illness.

When experimenting with sleep supplements, introduce only one product at a time and keep other major variables steady. Give it about a week to judge its effect, then decide whether to continue, swap, or combine it with something else. This makes it easier to tell what is actually helping and to stop quickly if a supplement causes a negative reaction.

Use Fadogia agrestis in short cycles rather than continuously: a common protocol is 3 weeks on followed by 1 week off. The rationale is to limit exposure because long-term safety data are still insufficient, so cycling is used as a precautionary approach.

Monitor the menstrual cycle to estimate when ovulation occurs, using cycle-length counting and, when available, intravaginal temperature changes around ovulation. This helps identify red flags and gives a clearer picture of hormonal function, not just fertility timing.

Try to conceive naturally for a set period before escalating to fertility treatment, with the waiting time adjusted by age. A common approach is roughly 5–6 months for women 30 and under, about 6–7 months in the early 30s, around 9–12 months in the mid-to-late 30s, and earlier consultation at 38 or older. This balances giving conception a fair chance with avoiding unnecessary delay when age-related fertility decline makes time more important.

For recurring nightmares, write out the dream and then repeatedly rehearse a revised, calmer, or more positive version while awake over multiple days. The goal is to update the brain’s stored script so that if the nightmare returns, the new response is easier to access and the dream is less distressing.

Use low-mercury SMASH fish—such as salmon, sardines, anchovies, mackerel, and herring—as the main dietary source of omega-3 fats. This approach prioritizes whole-food omega-3 intake over supplements, while choosing smaller wild fish helps reduce mercury exposure. The goal is to support omega-3 status with a nutrient-dense protein source that is generally safer to eat regularly.

Structure training around a 7- to 9-day cycle instead of forcing everything into a calendar week. This lets you align workouts with recovery needs, sport demands, and real-life scheduling, which can improve consistency and reduce the pressure to cram sessions into a rigid seven-day split.

Organize training around focused blocks that last roughly 8 to 12 weeks, each built around one primary goal. Plan the next block in advance rather than deciding workout by workout, so you can progress a specific adaptation before switching emphasis. This creates clearer direction, better consistency, and more measurable gains over time.

Adjust training load, volume, or intensity based on your readiness and performance on that day instead of rigidly sticking to preset percentages from a prior max. The key is to use a defined framework for making those adjustments, which helps you train hard when you’re capable and back off when fatigue is high, improving consistency and reducing unnecessary strain.

End a set or endurance effort when form starts to break down, rather than pushing through sloppy mechanics. This keeps the work stimulus high while reducing unnecessary injury risk and fatigue, and in strength training it often captures most of the benefit without needing absolute failure.

Before squats, deadlifts, and other loaded resistance movements, take a full breath into the abdomen and tighten the abdominal wall, obliques, and spinal erectors into a stable “canister.” This intra-abdominal pressure helps stabilize the spine, improves force transfer, and lowers the risk of injury during heavy lifting.

When pressing without a spotter, use dumbbells instead of a barbell bench press. Dumbbells let each arm move independently, which can feel more shoulder-friendly and reduce the risk of getting pinned under a failed rep while also discouraging ego-driven loading.

Have a trained spotter or reliable training partner present for lifts where failure could be dangerous, especially heavy bench pressing and other max-effort attempts. The spotter can help with unracking, controlled assistance, and emergency bailout, which reduces injury risk and lets you train hard with more confidence.