Supplements

Use caution with antioxidant supplementation, especially vitamin C and vitamin E, during hypertrophy-focused training or post-exercise, because their anti-inflammatory/antioxidant effects may blunt training adaptations.

Do not use ashwagandha broadly just to lower cortisol; cortisol regulation should be strategic and based on actual need. Taking ashwagandha before training is described as counterproductive because suppressing cortisol may suppress adaptation.

Be cautious with estrogen blockers or aromatase inhibitors because excessively low estrogen can severely impair libido.

High doses of turmeric can strongly inhibit DHT and may reduce libido in some people; monitor individual response.

Hair-loss compounds such as finasteride are mentioned as agents that can reduce libido in some people.

Do not routinely take antioxidant supplements without a specific reason or testing, because they can cause problems and may blunt adaptation.

Mentioned as a possible anti-inflammatory aid with some potential benefit, mainly in more specific circumstances.

Mentioned as a possible anti-inflammatory aid with some potential benefit, mainly in more specific circumstances.

Mentioned together as omega-3 brain-health supplements they may still recommend because potential benefits may outweigh costs, though evidence is described as unimpressive.

Antifungal shampoo used to maintain hair and possibly improve hair number and diameter. Use 2 to 4 times per week with scalp contact time of 3 to 5 minutes. Seek at least 2% ketoconazole concentration. Possible side effects include irritation, dryness, thinning, and brittle hair.

Host notes sufficient biotin is important and suggests extra biotin from shampoo may help, though evidence is unclear; mentioned mainly in the context of offsetting ketoconazole-related dryness and brittleness and supporting keratin incorporation.

Potent 5-alpha reductase inhibitor used to reduce DHT, increase hair count, reduce hair loss, and increase hair thickness. Oral starting range suggested as 0.5 mg to 1 mg per day; host emphasizes starting low, waiting a long time before increasing, and considering up to 25 weeks before dose escalation. Effective blood level may be around 0.2 mg. Topical option discussed as 1 mL of 0.25% once per week as a practical starting regimen. Side effects can include reduced libido, reduced sexual function, reduced drive/motivation, depressive symptoms, and possible post-finasteride syndrome.

Very potent 5-alpha reductase inhibitor that reduces DHT by about 95% and works 2 to 5 times faster than finasteride for hair regrowth. Typical oral dose discussed as 0.5 mg to 2.5 mg. Associated with substantial side effects including reduced sex drive, reduced overall drive, increased estrogen/prolactin, and gynecomastia.

Supplementation is described as part of a comprehensive ADHD treatment approach alongside prescription drugs, behavioral treatments, and nutritional guidelines, and should be updated across development by knowledgeable clinicians.

Common post-MDMA crash supplement protocols using serotonin or dopamine precursors and magnesium are not evidence-based. 5-HTP, L-tryptophan, L-tyrosine, and magnesium may not aid recovery and could be detrimental.

Use supplements only if needed, after addressing behaviors and nutrition first.

Suppositories containing Valium can be used as a muscle relaxant to help symptoms of a tight pelvic floor; described as more of a Band-Aid than a true treatment.

Suppositories containing baclofen can be used as a muscle relaxant to help symptoms of a tight pelvic floor; described as more of a Band-Aid than a true treatment.

For hypoactive sexual desire disorder in premenopausal women; daily medication taken before bedtime at 100 mg/day. Works in about 45–60% of patients and may be costly because it is brand name.

Use cranberry with 36 mg of proanthocyanidins (PACs) in a soluble form; not whole-berry formulations using skin/stem. Taken as a capsule once per day for recurrent UTI prevention. For women who tend to get post-coital UTIs, an option is two capsules on the day of sex and two the day after; noted as lower-data but low-risk.

Take about 2 grams per day of D-mannose, mixed as a drink, to help reduce UTI risk.

Probiotics are used by some people for UTI prevention, though the guest notes heterogeneity and uncertainty about which are effective vaginally.

If a kidney stone is not accompanied by infection symptoms, conservative treatment can include pain medication while waiting for passage.

Used both for kidney stone passage and enlarged prostate/BPH symptoms. It relaxes ureteral smooth muscle to allow a stone to pass more easily and, as an alpha blocker, helps enlarged prostate symptoms by relaxing the area and allowing urine to pass more easily.

Can be added if medication changes are not possible and SSRIs are contributing to erectile dysfunction.

For people with lifelong, chronically high anxiety, the speaker suggests that a small amount of medication to reduce baseline anxiety may be helpful long term; no specific compound or dosage is named.

Mentioned as reducing negative feeling; discussed as affecting affective state.

400–800 mg daily, usually with a meal; taken for vascular function and blood flow, not for lifespan extension; described as reasonably safe at those dosages and relatively low cost.

Oral phosphodiesterase inhibitor used as first-line treatment for erectile dysfunction; usually started in the middle-to-higher dose range and often used on demand.

Oral phosphodiesterase inhibitor option for erectile dysfunction.