Supplements

Mentioned as reducing negative feeling; discussed as affecting affective state.

400–800 mg daily, usually with a meal; taken for vascular function and blood flow, not for lifespan extension; described as reasonably safe at those dosages and relatively low cost.

Oral phosphodiesterase inhibitor used as first-line treatment for erectile dysfunction; usually started in the middle-to-higher dose range and often used on demand.

Oral phosphodiesterase inhibitor option for erectile dysfunction.

Oral phosphodiesterase inhibitor option for erectile dysfunction.

FDA-approved medication for Peyronie's disease that dissolves scar tissue.

Needed along with estrogen replacement to avoid unopposed estrogen and increased endometrial cancer risk; can be taken daily or cyclically.

Intranasal administration; early autism studies used a single dose of 24 international units. In the Stanford trial discussed, children received oxytocin twice per day for 4 weeks, and those with lower pretreatment blood oxytocin showed greater benefit.

Intranasal vasopressin administered twice daily for 4 weeks in children ages about 6 to 12 years with autism was associated with improved social abilities on parent reports, clinician evaluations, and laboratory-based tests in a randomized, placebo-controlled trial. Because vasopressin affects blood pressure and other important systems, it should not be used without medical supervision.

Proprietary fiber product described as reducing absorption of glucose by 36%, fructose by 38%, sucrose by 40%, and simple starches by 9%, while increasing short-chain fatty acid production by 60% without increasing gas; taken with meals as a one-teaspoon sachet sprinkled on food or mixed into a drink.

Typical over-the-counter NSAID; typically taken twice a day; take with food and fluids; avoid on an empty stomach; consult clinician first if you have GI bleeding issues, kidney issues, or heart issues.

Prescription COX-2 inhibitor that works similarly to ibuprofen and naproxen but is less irritating on the stomach.

Use xylitol in gum or mint form, especially immediately after meals. Start slowly with one or two after a meal rather than using large amounts all day. Xylitol is preferentially consumed by Streptococcus mutans, which cannot produce acid from it; it may inhibit or kill S. mutans, reduce gum inflammation, and increase saliva production, particularly when used after an early-day or noon meal.

May be supplemented as prebiotic or probiotic fiber to support the gut microbiome if needed.

Drug class discussed as improving working memory by inhibiting the enzyme that breaks down dopamine in prefrontal cortex.

Blood pressure medication discussed as boosting norepinephrine and gaining traction for improving working memory/executive symptoms; quote also mentions a study suggesting benefit for post-COVID brain fog symptoms.

Guest says he would steer away from Adderall and Ritalin for cognition optimization because they boost multiple catecholamine systems at once—dopamine, epinephrine, and norepinephrine—giving less control over modulation.

Avoid taking very high doses of curcumin; excessive anti-inflammation supplementation may have downsides, including potentially limiting dehydrotestosterone production.

Synthetic full-length peptide modeled on a thymus-derived peptide; used for tissue rejuvenation and repair. Often discussed alongside TB-500. No specific dose given.

Long-lasting type 1 growth-hormone-promoting peptide, typically taken twice per week or even once per week because effects on growth hormone and IGF-1 last several days. Host advises against specifically selecting it until safety issues are resolved due to a death in a clinical trial and possible fluid-retention/cardiovascular concerns.

Type 2 growth-hormone-promoting peptide. Discussed as part of the GHRP class designed to increase growth hormone; this class may also raise cortisol and prolactin. No specific dose given.

Type 2 growth-hormone-promoting peptide that can potently increase growth hormone, but is also known to potently increase prolactin and cortisol, sometimes more than doubling circulating cortisol. No specific dose given.

For nicotine-addicted teens, discussed as treatment using a nicotine patch plus supplemental nicotine gum or lozenges; one patch is about 21 mg nicotine, and some clinicians use one patch with gum/lozenges because teens may be consuming much more nicotine than that. Mentioned as treatment for weaning off nicotine, not as a starting product.

Shown to improve L-cell differentiation; dose not settled.

Green tea compound mentioned as stimulating GLP-1.

Discuss with a physician for sleep maintenance, especially in older adults; described as more helpful for keeping people asleep. Lower doses of 3 mg and 6 mg were mentioned. For the liquid solution, a standard starting dose of around 0.5 mL was mentioned, taken in a drink in the last half hour before bed.

Discuss with a physician; mentioned as a newer class of sleep drugs called the Doras.

For menopause-related sleep disruption, discuss bioidentical hormone replacement therapy with a physician; described as potentially helping sleep by bringing symptoms back under control and renormalizing aspects of reproductive hormones.

Suggested as a magnesium form to focus on for bioavailability.

Used for a skin/microbiome issue with rapid benefit; also recommended now and again when traveling or sleep deprived, and to help counter the effects of antibiotics.