Supplements

Recommended for sleep support in menopause; take orally at night before bed. Said to help settle the brain, likely via GABA-related effects.

Suggested for arousal disorders where desire is present but blood flow/arousal is inadequate.

FDA-approved libido medication taken daily; described as working at the level of dopamine/neurotransmitters in the brain.

For patch-related skin reactions, spray Flonase on the skin and let it dry before applying the estradiol patch to reduce adhesive reaction risk.

Beneficial protein supplement containing alpha-lactalbumin, lactoferrin, and immunoglobulins; whey protein isolate may be preferable instead if lactose is an issue.

Do not supplement zinc alone without considering copper because zinc and copper balance each other and there is a zinc-copper ratio maintained in the body.

500 mg twice per day for a total of 1,000 mg/day; may increase ceramides, improve skin moisture, reduce inflammation, balance oil production, reduce clogged pores, and reduce hyperpigmented spots. Effects may require 3–6 months or more.

Use topical niacinamide in ointments or serums at 2% to 10% concentration for skin benefits.

Use as a supplement or in topical serums/ointments to help hold moisture in skin and support a plump, youthful appearance.

Non-prescription topical retinoid esters may improve youthful appearance of skin; evidence is less robust than prescription retinoids.

Topical salicylic acid may help acne by reducing keratinocyte stickiness and swelling; apply only to clean skin and use if recommended by a dermatologist.

A little topical corticosterone cream can reduce redness or swelling of an acne pimple, especially for short-term cosmetic reasons.

Prescription drugs targeting immune pathways such as interleukin-17 and interleukin-23 for psoriasis; described as very effective.

Very high doses of polyphenols were mentioned as part of an aggressive longevity approach.

Peter takes methyl B12 alongside methylfolate to lower homocysteine; Huberman also says he takes methyl B12.

Peter specifically avoids supplementing B6 because over-supplementing vitamin B, especially B6, may be problematic and can cause peripheral nerve damage.

Peter takes magnesium oxide as one of three forms of magnesium he uses.

Peter takes Pendulum probiotic products and says he believes Pendulum is the only probiotic with meaningful effects because it includes anaerobic bacteria such as Akkermansia.

Akkermansia is taken via Pendulum and is described as an anaerobic probiotic that works through the GLP-1 butyrate pathway.

Peter takes Pendulum's product called Glucose Control.

Use dermatologist-prescribed retinoids to improve collagen composition from the inside out; requires staying out of the sun for some period because they increase sun sensitivity.

An oral supplement the guest personally takes for internal sun protection; described as providing an internal sun shield and allowing longer sun exposure without reapplication. Later described as a single scoop mixed into a morning drink and containing polypodium plus nicotinamide.

Oral fern-derived supplement for sun protection; increases minimal erythema dose and can be taken daily or about an hour before sun exposure. Common studied doses range roughly 50-480 mg. Possible side effect is upset stomach. Useful for fair skin, sun hives/PMLE, sports or water exposure, and melasma.

Non-steroidal topical anti-inflammatory medications used for vitiligo.

New creams and oral medications for refractory vitiligo; discussed as part of the recent renaissance in vitiligo treatment and immune-pathway targeting.

For papulopustular rosacea, oral medications can suppress bacterial and mite growth as well as the immune response in the skin.

May be used by a dermatologist for a severe pimple that needs to resolve immediately; should be done cautiously by an experienced dermatologist using low concentrations, usually on the bottom half of the face, due to risk of a permanent atrophic divot if overdosed.

Strongly recommended for sexually active adults and broadly for the population; on-label use now extends into the late 40s for both men and women.

Preferred GLP-1/GIP agonist for weight loss and glucose control; discussed alongside semaglutide as being used in compounded microdoses, starting very low and titrating slowly to reduce nausea and muscle loss. Also mentioned in combination with sermorelin to offset muscle loss.

Physician-prescribable anabolic steroid that can be combined with testosterone; described as helping joints and bone-related issues in some contexts.