Supplements

A dopamine-agonist medication used to lower prolactin, typically discussed as a targeted hormonal intervention rather than a general supplement. In the podcast context it comes up as a possible post-MDMA crash strategy because boosting dopamine and suppressing prolactin could, in theory, help with recovery, though there are no human trial data for that use yet.

A local estrogen therapy used for genitourinary syndrome of menopause, especially when vaginal dryness, irritation, or recurrent UTIs are the main issues. It’s typically applied as a low-dose vaginal cream, tablet, or ring, with the goal of restoring urogenital tissue health and lowering UTI recurrence without meaningfully systemic absorption. Because the dose is local and small, it’s generally considered very safe for long-term use.

A low-dose dopamine agonist protocol used to support cognition, especially working memory in people with lower baseline dopamine. The idea is that modest dopamine stimulation can sharpen prefrontal signaling and improve focus/mental control, and the doses discussed in healthy people were described as generally safe and often subjectively helpful.

A growth-hormone–promoting peptide used to stimulate endogenous GH release. It’s discussed as part of the GHRP class, which is intended to raise growth hormone but may also increase cortisol and prolactin. No specific dosing protocol was provided.

An orally absorbed growth-hormone secretagogue used to stimulate appetite and support muscle maintenance, especially in older adults who struggle to keep weight on. It’s typically taken earlier in the day rather than at bedtime, since it can increase hunger and may disrupt sleep if dosed too late.

An FDA-approved self-injected libido medication used before sexual activity, typically about 30 minutes ahead of time. It works through the melanocortin/alpha-melanocyte-stimulating hormone pathway to help increase sexual desire, and is prescribed for premenopausal hypoactive sexual desire disorder with some off-label use for vitality/libido.

A synthetic peptide used to mimic the body’s own kisspeptin signaling, typically in contexts where clinicians want to stimulate the reproductive hormone axis. It’s used to nudge upstream pathways that can influence libido and downstream testosterone/estrogen production, especially in hypothalamic or related endocrine settings.

A coated, slow-release magnesium chloride supplement taken to deliver magnesium more gradually. The slower release is meant to be gentler on the stomach and better tolerated than standard forms, while still supporting magnesium intake.

A prescription-strength topical retinoid approach for improving skin texture and aging signs, typically using tretinoin rather than over-the-counter retinol. It works by speeding skin-cell turnover and supporting collagen and new skin formation, which can help smooth acne, fine lines, and overall skin renewal. Dermatologists note it may be started as early as the 20s when appropriate, but it should be avoided during pregnancy or breastfeeding.

A prescription growth-hormone–releasing peptide used to strongly amplify natural GH pulses. It’s typically chosen for its very potent effect on GH secretion, which can exceed other peptides, but it also carries tradeoffs like higher prolactin, fluid retention, and other side effects.

A carefully dosed methylene blue protocol used as a mitochondrial-targeted adjunct when lifestyle and ketogenic strategies still leave room for improvement. The emphasis is on controlled use rather than high dosing, because the intended benefit is supporting cellular energy production while avoiding adverse effects from excess.

A peptide used to support sexual desire and arousal, especially discussed for women and sometimes for erectile dysfunction in men. It’s typically used as a targeted libido aid rather than a general wellness supplement, but it has a narrow therapeutic window and can cause nausea and tanning-like skin darkening, so dosing and tolerance matter.

A targeted B-vitamin approach focused on methylation support, especially when deficiency is suspected or confirmed. In the cited use case, it was given therapeutically to a woman with cognitive decline and severe methylation/B-vitamin deficiency, with the broader rationale that these vitamins help drive detoxification and other methylation-dependent pathways.

A biomimetic hydroxyapatite ingredient used in toothpaste or tooth tablets to support enamel repair and remineralization. It’s taken as part of daily oral care to help fill in early microscopic cavities, strengthen teeth, and promote a brighter, healthier-looking smile by supporting a more balanced oral environment.

A powerful plant-medicine psychedelic used in a controlled, curated, physician-assisted setting. In the cited protocol it was paired with ibogaine two days apart as an intensive “nuclear option” approach. The appeal is its potential for a profound, high-impact reset, but it is explicitly not appropriate for everyone.

This practice is to avoid taking iron supplements unless there is a clear medical reason or confirmed deficiency. The rationale is that excess supplemental iron may accelerate aging by promoting senescent cells, so mildly low hemoglobin, ferritin, or iron in otherwise healthy people may not justify routine supplementation.

Highlighted as a key electrolyte for hydration and neuronal function during exercise; no dosage provided.

Includes over-the-counter compounds such as Tylenol, Advil, and naproxen sodium, which can lower body temperature to some extent and are sometimes used by endurance athletes during long exertion. He advises thinking carefully before using them for performance because of potential liver/kidney effects and fluid/salt balance concerns.

CLA; can come from food or supplements; stimulates CCK release and helps blunt appetite.

May reduce blood glucose slightly.

Serotonergic drug mentioned as often effective in bulimia; also referenced in the broader class of serotonergic drugs used with limited success for anorexia. Prozac is the brand name; Paxil and Zoloft were mentioned as related serotonergic drugs.

2 grams; can reduce rhinitis/nasal obstruction, improve smell, improve sleep, reduce inflammatory cytokines, and reduce nasal itching. Caution for people with PKU/phenylalanine sensitivity.

Caffeine in pill form does not break a fast.

Look for probiotic products with independent validation, since labels may not match contents; prefer reputable brands with stronger quality control; when possible, choose the exact probiotic used in a well-designed study for your target symptom or indication, then experiment personally to see whether it works for you.

Presented as a supplement that can increase sexual desire and function in certain populations, particularly females, with mixed findings on testosterone and libido. Study protocols mentioned include 750 mg/day divided into 3 equal doses for 120 days, which increased free and bioavailable testosterone in postmenopausal women but not libido in that study, and 6 g/day of Tribulus root for 60 days, which was associated with a clear significant increase in libido in a separate study.

Discuss with a board-certified psychiatrist for bipolar disorder; requires careful blood monitoring due to toxicity, especially in the first three months. Presented as effective for reducing manic symptoms in many patients, but not something to self-administer casually.

Mentioned as a topical antiandrogen option for hair loss.

Discussed as likely only minimally systemically absorbed and not affecting systemic DHT, making it a potentially preferable topical antiandrogen for hair loss.

For vegans, isolated plant protein is recommended because whole plant sources can make it difficult to get enough protein without excess calories.

Soy is recommended as one of the better vegan protein sources because it is a complete protein with a PDCAAS of 1; using it once or twice a day is said not to affect testosterone or estrogen.