Supplements

A low-dose dopamine agonist protocol used to support cognition, especially working memory in people with lower baseline dopamine. The idea is that modest dopamine stimulation can sharpen prefrontal signaling and improve focus/mental control, and the doses discussed in healthy people were described as generally safe and often subjectively helpful.

A growth-hormone–promoting peptide used to stimulate endogenous GH release. It’s discussed as part of the GHRP class, which is intended to raise growth hormone but may also increase cortisol and prolactin. No specific dosing protocol was provided.

An orally absorbed growth-hormone secretagogue used to stimulate appetite and support muscle maintenance, especially in older adults who struggle to keep weight on. It’s typically taken earlier in the day rather than at bedtime, since it can increase hunger and may disrupt sleep if dosed too late.

An FDA-approved self-injected libido medication used before sexual activity, typically about 30 minutes ahead of time. It works through the melanocortin/alpha-melanocyte-stimulating hormone pathway to help increase sexual desire, and is prescribed for premenopausal hypoactive sexual desire disorder with some off-label use for vitality/libido.

A synthetic peptide used to mimic the body’s own kisspeptin signaling, typically in contexts where clinicians want to stimulate the reproductive hormone axis. It’s used to nudge upstream pathways that can influence libido and downstream testosterone/estrogen production, especially in hypothalamic or related endocrine settings.

A coated, slow-release magnesium chloride supplement taken to deliver magnesium more gradually. The slower release is meant to be gentler on the stomach and better tolerated than standard forms, while still supporting magnesium intake.

Estrogen therapy for women in perimenopause or after menopause, typically discussed with a clinician and started early when appropriate. The common protocol emphasis is timing: benefits appear strongest when begun around ages 50–59 or within about 10 years of menopause, and it is often used to relieve hot flashes. It may also help preserve cognition and support skin, with possible cardiovascular benefit when started in that earlier window.

A prescription-strength topical retinoid approach for improving skin texture and aging signs, typically using tretinoin rather than over-the-counter retinol. It works by speeding skin-cell turnover and supporting collagen and new skin formation, which can help smooth acne, fine lines, and overall skin renewal. Dermatologists note it may be started as early as the 20s when appropriate, but it should be avoided during pregnancy or breastfeeding.

A prescription growth-hormone–releasing peptide used to strongly amplify natural GH pulses. It’s typically chosen for its very potent effect on GH secretion, which can exceed other peptides, but it also carries tradeoffs like higher prolactin, fluid retention, and other side effects.

A carefully dosed methylene blue protocol used as a mitochondrial-targeted adjunct when lifestyle and ketogenic strategies still leave room for improvement. The emphasis is on controlled use rather than high dosing, because the intended benefit is supporting cellular energy production while avoiding adverse effects from excess.

A peptide used to support sexual desire and arousal, especially discussed for women and sometimes for erectile dysfunction in men. It’s typically used as a targeted libido aid rather than a general wellness supplement, but it has a narrow therapeutic window and can cause nausea and tanning-like skin darkening, so dosing and tolerance matter.

A targeted B-vitamin approach focused on methylation support, especially when deficiency is suspected or confirmed. In the cited use case, it was given therapeutically to a woman with cognitive decline and severe methylation/B-vitamin deficiency, with the broader rationale that these vitamins help drive detoxification and other methylation-dependent pathways.

A biomimetic hydroxyapatite ingredient used in toothpaste or tooth tablets to support enamel repair and remineralization. It’s taken as part of daily oral care to help fill in early microscopic cavities, strengthen teeth, and promote a brighter, healthier-looking smile by supporting a more balanced oral environment.

A powerful plant-medicine psychedelic used in a controlled, curated, physician-assisted setting. In the cited protocol it was paired with ibogaine two days apart as an intensive “nuclear option” approach. The appeal is its potential for a profound, high-impact reset, but it is explicitly not appropriate for everyone.

This practice is to avoid taking iron supplements unless there is a clear medical reason or confirmed deficiency. The rationale is that excess supplemental iron may accelerate aging by promoting senescent cells, so mildly low hemoglobin, ferritin, or iron in otherwise healthy people may not justify routine supplementation.

5 mg edible, used about twice a week when amped up or expecting trouble sleeping; prefers edibles for dosing control.

Highlighted as a key electrolyte for hydration and neuronal function during exercise; no dosage provided.

Highlighted as a key electrolyte for hydration and neuronal function during exercise; no dosage provided.

Mentioned as part of a studied combination with probiotics and a low-ish dose of coenzyme Q10 that reduced symptoms of major depression in the short term.

Capsule form can be used to support the gut microbiome.

He does not recommend it strongly; evidence suggests little to no benefit. If used anyway, reserve it for when feeling run down or for the highest-risk winter month, not continuously and not for more than 4 weeks.

If ferritin is low or low-normal, consider supplementing rather than waiting for overt deficiency. In active women, ferritin around 20 to 25 may be called normal, but the target discussed is closer to 50. If concerned about low ferritin, take an iron supplement every other day starting on the first day of bleeding for 10 days to improve absorption.

Adaptogenic plant used for focus and brain fog; Dr. Sims puts it in morning coffee and again in the afternoon instead of more caffeine. Described as regulating dopamine, serotonin, and cortisol.

Pre-high-intensity stack: 200 mg caffeine, low-dose baby aspirin, and beta-alanine; used to enhance top-end training stress. She cautions not to stack high-intensity days back-to-back when using it.

Suggested adaptogen option; holy basil and tulsi refer to the same herb.

Suggested medicinal mushroom option among favored adaptogenic supports.

Sleep-support compound that impacts the GABA system and chloride channels; found in many supplements designed to increase sleepiness and sleep.

Use caution with evening primrose oil because it has estrogenic properties and may alter estrogen levels, including through skin contact; especially relevant around children or if trying to avoid promoting estrogenic pathways.

Hair-loss drugs that inhibit 5-alpha reductase may reduce DHT and can carry severe side effects in many individuals, including effects related to libido, strength, connective tissue repair, and aggression/ambition.

Algal oil can be used as an alternative omega-3 source for people avoiding fish oil. Some people tolerate and like it, though it may cause skin itchiness in some individuals.