Supplements

A stimulant approach using yohimbine or alpha-yohimbine to increase alertness and sharpen focus. It works by activating adrenergic pathways, which can make it useful when you want a more noticeable mental and physical drive without changing the rest of your routine.

Take about 1 to 3 g per day of betaine as a steady daily supplement. It’s especially useful for people with persistently elevated homocysteine, since betaine helps support methylation and homocysteine recycling. Some also use it when they seem to be a creatine non-responder, and there’s no need to cycle it.

A low-dose naltrexone protocol used at roughly one-tenth the usual naltrexone dose, most often discussed for certain forms of fibromyalgia. The idea is that this very small dose may reduce glial activation via Toll-like receptor 4 blockade, which can help with pain and symptom burden.

Turmeric is used as a supplement for prostate support and general inflammation control, often taken in standard capsule or powder form. The appeal is its potential to calm inflammatory pathways, but it may not suit everyone and some people report reduced vitality or other intolerance effects, so it’s best approached cautiously.

If you’re prescribed Vyvanse, work with your clinician to choose the best time of day to take it rather than treating timing as fixed. The goal is to match the medication’s dopaminergic effect to your schedule so you get symptom control when you need it most while reducing unwanted insomnia or late-day overstimulation.

Vitamin E is used as part of an inflammation-focused supplement stack for women with endometriosis, often alongside L-carnitine, N-acetylcysteine, and vitamin C. The goal is to help calm inflammatory processes that may contribute to endometriosis-related pain and symptoms.

Use a small daily aspirin dose, typically 81 mg or two baby aspirin, for athletes dealing with training-related inflammation. It’s often paired with fish oil and specialized pro-resolving mediators to support the body’s inflammation-resolution pathways rather than simply masking pain. The goal is to blunt excessive exercise-induced inflammation while staying in a low-dose, more targeted range.

Supplement vitamin A only when dietary intake is likely insufficient or a deficiency risk is present; for most people, food sources are enough. Small amounts included in a foundational or multivitamin formula are generally considered fine, but routine high-dose standalone use is usually unnecessary and can raise toxicity concerns.

A morning supplement routine using green tea in capsule form, typically taken as a couple of capsules after waking. It’s used as a convenient way to capture green tea’s bioactive compounds without brewing tea, often for a mild stimulant and antioxidant effect that supports alertness and general metabolic health.

Aspirin is a common over-the-counter pain reliever used for headaches, typically taken at the first sign of pain. It can reduce headache discomfort by dampening inflammation and pain signaling, but it may be a poor choice for migraine in some people because migraine can involve blood-vessel changes that aspirin may not address well.

Licorice root is used in very small doses to help raise cortisol, which can be useful when someone is trying to support low stress resilience or adrenal output. Start with the lowest possible capsule dose because it can be potent, and avoid it during pregnancy, breastfeeding, or if you have high blood pressure.

A beet-derived nitrate strategy used before moderate-to-long endurance efforts, typically as beetroot juice or beet powder. It boosts nitric oxide and vasodilation, which can improve blood flow and oxygen delivery to working muscles and other tissues, making it useful when you want a performance edge during sustained exercise.

A carotenoid supplement used to support eye health, often discussed alongside lutein and astaxanthin. The practical idea is regular supplementation as part of a vision-focused stack, with the goal of helping maintain or improve visual function by supporting the retina and macular pigment. Current evidence suggests it is not known to be dangerous at typical use, though the research base is still limited.

Supplement choline to bring total daily intake into the 500 mg to 1 g range, with some people using smaller doses like 50–100 mg to top up toward 1 g or even 2 g per day. The goal is to support adequate choline status for functions like acetylcholine production, liver health, and overall methylation and membrane maintenance.

A daily moringa powder routine, typically using Kuli Kuli moringa and taking a heaping tablespoon mixed into smoothies. It’s used as a sulforaphane-like Nrf2 activator, aiming to support the body’s antioxidant and cellular defense pathways.

A vegan-friendly omega-3 strategy that uses microalgae-derived oil as a direct source of DHA. It’s favored over relying on flaxseed or other ALA sources because conversion of ALA to DHA is inefficient, so algal oil more reliably supports DHA intake for people avoiding fish.

A boron supplement protocol used to help regulate sex hormone-binding globulin, with the effect described as mostly acute. A common approach is 3 to 6 mg once or twice daily, and some suggest cycling it rather than taking it continuously. The appeal is its potential to shift SHBG and thereby influence free hormone availability.

A prescription medication sometimes used off-label at bedtime to help people who have trouble falling asleep. It’s typically taken in the evening under a physician’s guidance, with the goal of making sleep initiation easier through its sedating effects.

Bioidentical micronized progesterone is commonly used alongside estrogen in women who still have a uterus, typically at a systemic dose around 100–200 mg. Beyond its role in endometrial protection, it can improve sleep in some women, likely through its calming, sedative-like effects.

An FDA-approved estradiol replacement approach used for menopause hormone therapy, most commonly delivered as a transdermal patch. The patch provides bioidentical estradiol in a steadier, more physiologic way than older oral conjugated estrogen regimens, helping replace declining estrogen while avoiding some first-pass liver effects.

An intermittent rapamycin protocol used as a geroprotective intervention, commonly taken at 8 mg once per week rather than daily. One described pattern is about two months on followed by one month off to reduce aphthous ulcers/canker sores. The appeal is its reputation as a strong longevity-focused molecule, with the dosing schedule aimed at preserving the anti-aging signal while improving tolerability.

An injectable PCSK9-lowering treatment used on a regular schedule, commonly every two weeks. It is used to drive LDL and ApoB down very aggressively, making it one of the most potent options for reducing atherogenic cholesterol burden.

A cholesterol-lowering medication that reduces intestinal absorption of cholesterol, typically used to help lower LDL levels. It’s generally well tolerated, with occasional loose stools and a small risk of elevated transaminases when combined with statins.

A caffeine ointment or cream is applied directly to the scalp, typically about three times per week. The idea is to inhibit PDE and support hair follicles by indirectly boosting IGF-1 and reducing apoptosis in the stem-cell niche, helping maintain hair growth.

Take 1,000 mg of lion’s mane daily as an adaptogenic supplement, then cycle off after about 30 days. It’s used to help buffer stress, with a proposed benefit of lowering cortisol and inflammatory cytokines.

Use essential amino acids alongside a meal when whole-food protein is too low to adequately stimulate muscle protein synthesis. The idea is to raise the amino acid threshold at that meal, helping cover gaps in protein intake and better support recovery and maintenance; branched-chain amino acids were mentioned as a less complete alternative.

A curcumin supplement used specifically in people with mild cognitive impairment. The rationale is that it may help preserve or improve cognitive function, with a relatively low downside profile and some reasonable evidence supporting benefit.

A low-dose oral minoxidil regimen used to slow hair loss and help maintain existing hair. The protocol discussed ranges from 0.25 mg to 5 mg once daily, typically starting at the lowest possible dose and adjusting as needed. It works by increasing blood flow and prolonging the anagen phase, which can support hair retention and growth.

A dopamine-agonist medication used to lower prolactin, typically discussed as a targeted hormonal intervention rather than a general supplement. In the podcast context it comes up as a possible post-MDMA crash strategy because boosting dopamine and suppressing prolactin could, in theory, help with recovery, though there are no human trial data for that use yet.

A local estrogen therapy used for genitourinary syndrome of menopause, especially when vaginal dryness, irritation, or recurrent UTIs are the main issues. It’s typically applied as a low-dose vaginal cream, tablet, or ring, with the goal of restoring urogenital tissue health and lowering UTI recurrence without meaningfully systemic absorption. Because the dose is local and small, it’s generally considered very safe for long-term use.