Supplements

Using stevia as a plant-based, non-sugar sweetener in moderation can replace sugar without meaningfully raising overall blood glucose for many people. Its effect on fasting glucose appears individual, so it’s best treated as a low-glycemic swap rather than a universally neutral one.

Using cannabidiol as a sleep aid, typically at around 50 mg or more, is the dominant recommendation here. The effect appears to be U-shaped: smaller doses under roughly 25 mg may be wake-promoting, while higher doses tend to be more sleep-promoting. It’s favored as a way to support sleep without THC’s intoxicating drawbacks.

Use semaglutide as a GLP-1 agonist for obesity and metabolic treatment, often finding meaningful benefit at about 1 to 2 mg weekly rather than pushing all the way to 2.4 mg. The practical advantage is that many people get strong appetite and weight-control effects at these lower doses while potentially limiting nausea and other dose-related side effects.

A common over-the-counter pain reliever used when you want analgesia without the stomach irritation associated with NSAIDs. Typical guidance is to stay at or below 4,000 mg per day in divided doses, and to be especially cautious if you have liver issues or drink heavily. It can be a practical option for many people because it reduces pain and fever while being gentler on the GI tract.

Amino acid supplements centered on branched-chain amino acids are generally considered unnecessary when total daily protein intake is already sufficient. If supplementing amino acids at all, a full essential amino acid blend is usually preferred because it provides the complete set needed for muscle protein synthesis rather than just the three BCAAs.

A daily 500 mg dose taken in the morning, usually within 1–2 hours of waking and about 30 minutes to 2 hours before the first meal. It’s used to raise NAD levels and is reported to support sustained mental and physical energy throughout the day.

Prescription GLP-1 medications are used as a medical tool for people with obesity, major weight-loss struggles, or related insulin resistance such as PCOS. They work by strongly activating GLP-1 signaling to reduce appetite and support meaningful weight loss, and they tend to work best when paired with lifestyle changes and nutrition education rather than used alone.

An over-the-counter alpha-lipoic acid supplement used mainly for neuropathic pain relief. It’s taken orally and is thought to help by scavenging free radicals and modulating T-type calcium channels, which may reduce nerve pain symptoms. It’s generally well tolerated, though some people get mild stomach upset.

Take about 1 to 3 g per day of betaine as a steady daily supplement. It’s especially useful for people with persistently elevated homocysteine, since betaine helps support methylation and homocysteine recycling. Some also use it when they seem to be a creatine non-responder, and there’s no need to cycle it.

A low-dose naltrexone protocol used at roughly one-tenth the usual naltrexone dose, most often discussed for certain forms of fibromyalgia. The idea is that this very small dose may reduce glial activation via Toll-like receptor 4 blockade, which can help with pain and symptom burden.

Using cannabis-derived THC and/or CBD to ease nausea, especially in settings like chemotherapy or radiation. The idea is to use it when nausea is the target symptom, since these compounds can reduce queasiness for some people. Effects are highly individual, so benefits may vary and some users can experience unwanted effects like paranoia.

If you’re prescribed Vyvanse, work with your clinician to choose the best time of day to take it rather than treating timing as fixed. The goal is to match the medication’s dopaminergic effect to your schedule so you get symptom control when you need it most while reducing unwanted insomnia or late-day overstimulation.

Aspirin is a common over-the-counter pain reliever used for headaches, typically taken at the first sign of pain. It can reduce headache discomfort by dampening inflammation and pain signaling, but it may be a poor choice for migraine in some people because migraine can involve blood-vessel changes that aspirin may not address well.

A carotenoid supplement used to support eye health, often discussed alongside lutein and astaxanthin. The practical idea is regular supplementation as part of a vision-focused stack, with the goal of helping maintain or improve visual function by supporting the retina and macular pigment. Current evidence suggests it is not known to be dangerous at typical use, though the research base is still limited.

Supplement choline to bring total daily intake into the 500 mg to 1 g range, with some people using smaller doses like 50–100 mg to top up toward 1 g or even 2 g per day. The goal is to support adequate choline status for functions like acetylcholine production, liver health, and overall methylation and membrane maintenance.

A PCOS-focused inositol protocol for women that pairs D-chiro-inositol with myo-inositol, typically at about 1:25 to 1:40 relative to the myo-inositol dose. The combination is used to help balance androgens and support metabolic/hormonal regulation, especially when PCOS or androgen excess is a concern.

A weak 5-alpha reductase inhibitor used mainly to help slow hair loss and sometimes support modest regrowth. Typical dosing is about 300 mg per day, with studies ranging from 200 to 500 mg daily, usually split into 2 or 3 doses. The rationale is to reduce DHT activity, which may help preserve follicles over time.

A short course of clomiphene used in younger men with low testosterone when the problem is inadequate pituitary signaling rather than primary testicular failure. A typical protocol is 50 mg three times per week for 8–12 weeks, followed by reassessment. It can raise endogenous testosterone by stimulating the body’s own hormone signaling instead of replacing testosterone directly.

A caffeine ointment or cream is applied directly to the scalp, typically about three times per week. The idea is to inhibit PDE and support hair follicles by indirectly boosting IGF-1 and reducing apoptosis in the stem-cell niche, helping maintain hair growth.

A supervised psychotherapy protocol using MDMA to help treat post-traumatic stress disorder. Typical clinical dosing is about 0.75 to 1.5 mg/kg, and some protocols use an initial dose followed by a half-dose booster 90 minutes to 2.5 hours later. The goal is to reduce fear and defensiveness during therapy, making traumatic material easier to process and integrate.

A controlled ibogaine protocol used in a curated, physician-supervised setting, often framed as a high-intensity intervention rather than a casual supplement. It’s discussed as a “nuclear option” for deep reset or addiction-related work, with the appeal being its powerful, short-term psychoactive effects and the possibility of catalyzing major behavioral change under close medical oversight.

A high-dose intravenous NAD regimen used as a clinical “reset” protocol: commonly about 750 mg per infusion, given as a loading series of 5 treatments over 10 days, then maintained roughly monthly. The appeal is its reported strong impact on energy, recovery, and overall clinical response, with IV delivery allowing substantial dosing that can be titrated to tolerance.

Discussed as a local vaginal option because receptors can convert it into testosterone and estradiol. Intrarosa was named as a vaginal DHEA preparation used especially in sexual medicine and for some breast cancer patients to provide local testosterone/estradiol effects in vulvovaginal tissue.

Supplemental fiber; described as something many doctors are now recommending patients take a little bit of.

A melanocortin receptor agonist used to boost sexual desire, primarily for premenopausal women with hypoactive sexual desire disorder. It’s typically taken as a subcutaneous injection about 45–60 minutes before sexual activity, working through brain pathways involved in desire rather than as a direct hormone replacement. The main benefit is improved libido and sexual interest, with caution advised in people with a personal or family history of melanoma.

Use methylated forms of B vitamins—especially methylfolate, methyl B12, and methylated B6—when supplementing B vitamins, particularly if you have elevated homocysteine or suspected MTHFR-related methylation issues. The goal is to support methylation and help bring homocysteine down, which is often framed as a potential brain-health benefit even though the evidence is mixed.

A synthetic pineal-mimetic peptide used in intermittent courses rather than as a daily supplement. It’s typically discussed as part of broader circadian-focused longevity protocols, with the goal of supporting sleep-wake signaling while also being explored for anti-inflammatory and telomere-supportive effects.

A prophylactic thymosin alpha-1 protocol used during travel and hospital work to reduce the chance of getting sick. The reported approach was 2.5 mg twice weekly, taken without regard to timing. It’s framed as an immune-support strategy for periods of high exposure risk.

A small 99 mg potassium tablet is taken with water, often paired with salt, either before training or during fasting. The goal is to support electrolyte balance so people feel mentally clearer and can sustain physical or mental work capacity, especially on low-carb or low-calorie days.

A medically supervised hormone replacement protocol used to restore low testosterone levels. It’s taken under a doctor’s guidance and is associated with feeling younger, improved strength and gym performance, better erections, and even skin benefits by correcting hormonal deficiency.