Supplements

Using cannabis-derived THC and/or CBD to ease nausea, especially in settings like chemotherapy or radiation. The idea is to use it when nausea is the target symptom, since these compounds can reduce queasiness for some people. Effects are highly individual, so benefits may vary and some users can experience unwanted effects like paranoia.

Vitamin B6 is used as a prolactin-lowering supplement, often included in testosterone-support stacks. The idea is that reducing prolactin may help shift the dopamine balance upward, which is why it’s sometimes taken for hormonal support or after major stressors/events.

Astaxanthin is a carotenoid supplement commonly discussed alongside lutein and zeaxanthin for eye health. The recurring use case is supporting or maintaining vision, with the appeal being that it appears unlikely to be dangerous based on current evidence, though the evidence base is still limited.

An over-the-counter acetylcholine-boosting compound used to create a short-lived window of enhanced plasticity, often paired with exercise. It works by increasing cholinergic signaling, which can also support downstream dopamine activity in brain regions tied to learning and focus.

Maca is typically taken as 2–3 g per day in powder or capsule form, usually earlier in the day because it can feel mildly stimulating and may disrupt sleep if taken late. It’s used mainly to improve libido, with reports of benefit in women, men, and people with SSRI-related sexual side effects, possibly through dopamine and upstream hormone pathways.

A PCOS-focused inositol protocol for women that pairs D-chiro-inositol with myo-inositol, typically at about 1:25 to 1:40 relative to the myo-inositol dose. The combination is used to help balance androgens and support metabolic/hormonal regulation, especially when PCOS or androgen excess is a concern.

A weak 5-alpha reductase inhibitor used mainly to help slow hair loss and sometimes support modest regrowth. Typical dosing is about 300 mg per day, with studies ranging from 200 to 500 mg daily, usually split into 2 or 3 doses. The rationale is to reduce DHT activity, which may help preserve follicles over time.

A short course of clomiphene used in younger men with low testosterone when the problem is inadequate pituitary signaling rather than primary testicular failure. A typical protocol is 50 mg three times per week for 8–12 weeks, followed by reassessment. It can raise endogenous testosterone by stimulating the body’s own hormone signaling instead of replacing testosterone directly.

A supervised psychotherapy protocol using MDMA to help treat post-traumatic stress disorder. Typical clinical dosing is about 0.75 to 1.5 mg/kg, and some protocols use an initial dose followed by a half-dose booster 90 minutes to 2.5 hours later. The goal is to reduce fear and defensiveness during therapy, making traumatic material easier to process and integrate.

A controlled ibogaine protocol used in a curated, physician-supervised setting, often framed as a high-intensity intervention rather than a casual supplement. It’s discussed as a “nuclear option” for deep reset or addiction-related work, with the appeal being its powerful, short-term psychoactive effects and the possibility of catalyzing major behavioral change under close medical oversight.

A high-dose intravenous NAD regimen used as a clinical “reset” protocol: commonly about 750 mg per infusion, given as a loading series of 5 treatments over 10 days, then maintained roughly monthly. The appeal is its reported strong impact on energy, recovery, and overall clinical response, with IV delivery allowing substantial dosing that can be titrated to tolerance.

Serotonin-boosting sleep supplements such as tryptophan and 5-HTP are generally approached with caution or avoided, especially when they seem to worsen sleep. The concern is that increasing serotonin can alter normal REM and slow-wave sleep timing, leading to falling asleep deeply at first but waking a few hours later or otherwise having more fragmented sleep.

A melanocortin receptor agonist used to boost sexual desire, primarily for premenopausal women with hypoactive sexual desire disorder. It’s typically taken as a subcutaneous injection about 45–60 minutes before sexual activity, working through brain pathways involved in desire rather than as a direct hormone replacement. The main benefit is improved libido and sexual interest, with caution advised in people with a personal or family history of melanoma.

Use methylated forms of B vitamins—especially methylfolate, methyl B12, and methylated B6—when supplementing B vitamins, particularly if you have elevated homocysteine or suspected MTHFR-related methylation issues. The goal is to support methylation and help bring homocysteine down, which is often framed as a potential brain-health benefit even though the evidence is mixed.

A synthetic pineal-mimetic peptide used in intermittent courses rather than as a daily supplement. It’s typically discussed as part of broader circadian-focused longevity protocols, with the goal of supporting sleep-wake signaling while also being explored for anti-inflammatory and telomere-supportive effects.

A prophylactic thymosin alpha-1 protocol used during travel and hospital work to reduce the chance of getting sick. The reported approach was 2.5 mg twice weekly, taken without regard to timing. It’s framed as an immune-support strategy for periods of high exposure risk.

A small 99 mg potassium tablet is taken with water, often paired with salt, either before training or during fasting. The goal is to support electrolyte balance so people feel mentally clearer and can sustain physical or mental work capacity, especially on low-carb or low-calorie days.

A medically supervised hormone replacement protocol used to restore low testosterone levels. It’s taken under a doctor’s guidance and is associated with feeling younger, improved strength and gym performance, better erections, and even skin benefits by correcting hormonal deficiency.

A peptide used for tissue rejuvenation and repair, typically discussed as a truncated form of thymosin beta-4. It’s often paired with thymosin beta-4 or BPC-157 in recovery-focused protocols, with the goal of supporting healing and regeneration after injury or strain.

Use semaglutide as a GLP-1 agonist for obesity and metabolic treatment, often finding meaningful benefit at about 1 to 2 mg weekly rather than pushing all the way to 2.4 mg. The practical advantage is that many people get strong appetite and weight-control effects at these lower doses while potentially limiting nausea and other dose-related side effects.

This is the use of 5-MTHF/methylfolate as a targeted folate form to reduce elevated homocysteine. The idea is that supporting the remethylation of homocysteine to methionine can help raise endogenous SAMe and may improve nitric-oxide-related vascular function by bringing homocysteine down.

Amino acid supplements centered on branched-chain amino acids are generally considered unnecessary when total daily protein intake is already sufficient. If supplementing amino acids at all, a full essential amino acid blend is usually preferred because it provides the complete set needed for muscle protein synthesis rather than just the three BCAAs.

A small Pinealon injection is used if waking in the middle of the night, with the goal of boosting REM sleep in the final hours of the sleep cycle. The protocol is occasional rather than nightly, and the intended benefit is to improve late-night REM when it would otherwise be missed.

A daily prenatal vitamin taken before pregnancy, ideally throughout the reproductive years rather than only after conception. The goal is to build nutrient stores in advance, especially folate/folic acid, which supports early fetal development and helps reduce the risk of neural tube defects.

Taking sodium bicarbonate before training is used as a buffering aid to help delay fatigue caused by exercise-induced acidity. A common practical approach is to use store-bought baking soda, starting with a low dose to reduce the risk of gastric distress and then adjusting as tolerated. The goal is to improve high-intensity performance by helping the body handle acid buildup more effectively.

Using medium-chain triglycerides as a replacement for some other dietary fat, often around 1–2 tablespoons per day, is a common protocol. It’s discussed as a way to support weight loss because MCTs are rapidly metabolized and may increase thermic effect of food while providing fat calories that are less likely to spike blood glucose or insulin.

Use NSAIDs when pain is interfering with daily life, work, sleep, or time with family and friends, rather than for minor soreness. The practical approach is to use the lowest effective dose that gives meaningful relief, since these drugs can reduce pain and recovery burden but may also blunt training adaptation by dampening the inflammation needed for hypertrophy.

A short-term, low-dose aspirin protocol discussed for the first two weeks after losing a loved one, framed as a cardioprotective proof-of-concept rather than established medical guidance. The idea is that acute grief can transiently raise cardiovascular risk, so temporary antiplatelet support may help blunt clot-related events during that vulnerable window.

A vitamin B6 metabolite used as a recovery aid after MDMA, typically taken with the goal of blunting the comedown. The rationale is that P5P may suppress prolactin, which could help with mood and recovery after the drug wears off, though the evidence cited is mechanistic rather than based on human clinical trials.

Supplement calcium when dietary intake is insufficient, especially if you’re concerned about maintaining bone health. The idea is to help ensure adequate calcium availability to support bone density and reduce osteoporosis risk, including in contexts where caffeine intake may be a concern.